Pālolo is the name of a valley, stream, and residential neighborhood in Honolulu, Hawaii, the United States.

The makai (ocean-side) of the valley ends approximately at Waiʻalae Avenue and is densely settled, mostly with single-family homes.

In the Hawaiian land use system, Pālolo is an ʻili of the Waikīkī ahupuaʻa in moku of Kona (Honolulu).

[3] Pālolo includes the Kaʻau Crater, an extinct volcano in the mountains at the back of the valley.

Pālolo Valley is bordered on the mauka end by the Koʻolau Range, to the Koko Head (approximately East) side by Wilhelmina Rise, on the makai end by the neighborhood of Kaimuki, and on the ʻEwa (approximately west) side by Waʻahila Ridge.