In her second term, Iorio advocated for improved mass transit, favoring a multi-modal plan which included a light rail system.

[4] In her official capacity as mayor, Iorio represented the city at important events such as the opening of the Tampa Bay History Center on January 17, 2009.

On January 28, 2010, when Iorio welcomed U.S. President Barack Obama and Vice President Joe Biden, Governor of Florida Charlie Crist, and Chief Financial Officer Alex Sink, all of whom came to the University of Tampa for a national "Town Hall Meeting" to announce federal funding for Florida High Speed Rail and other projects.

[5] Iorio criticized Florida Governor Rick Scott's decision to veto the high speed rail project, claiming he did so "purely on ideological reasoning.

She has been involved with the Tampa Bay History Center, the Curtis Hixon Park and Riverwalk, and the USF Foundation[8] She had been mentioned as a possible Democratic Party candidate for governor of Florida in 2014.