Brull played the stepmother of the title character (played by Mayim Bialik) and the mother of two others (one of whom was played by a teenaged Jennifer Aniston) in the short-lived sitcom Molloy.
Brull was featured in the pilot of the sitcom Seinfeld (1989).
Brull starred on Broadway (1990) in the original production of Rupert Holmes' Accomplice as the character 'Harley'.
She also performed the role at the Pasadena Playhouse where the play made its debut (1989).
Brull is a member of the Los Angeles based theatre company, INTERACT.