It replaced the original Alice Ho Miu Ling Nethersole Hospital in Mid-Levels in Hong Kong Island and moved to Chai Wan.

It is affiliated with the Li Ka Shing Faculty of Medicine, the University of Hong Kong, providing clinical attachment opportunities for its medical students.

When the Pamela Youde Nethersole Eastern Hospital opened, the accident and emergency unit of the Chai Wan Health Centre moved to the new complex.

[4] Pamela Youde Nethersole Eastern Hospital is the only hospital in Hong Kong which houses a pressure chamber to provide Hyperbaric Oxygen Therapy (HBOT) service, which can be used to treat conditions such as air or gas embolism, carbon monoxide poisoning, central retinal artery occlusion (CRAO), decompression sickness, etc.

[5] Under the Hong Kong government's Daya Bay Contingency Plan, the two centres will treat and decontaminate persons affected by a nuclear accident.