He joined the Hellenic Army as a volunteer in 1910 and fought in the Balkan Wars of 1912–1913.

He subsequently entered the NCO Academy and graduated as an Infantry Second Lieutenant in April 1914.

[1] In 1944, at the eve of the Germans' departure from Greece, Spiliotopoulos was appointed as the representative in Athens and its suburbs of the Allies' Middle East High Command.

Following liberation in October 1944, Spiliotopoulos became head of the Athens Military Command, and soon after commander of the new Officers' Training Centre before being appointed as Chief of the Hellenic Army General Staff on 16 May 1946, a post he held until 19 February 1947.

[1] Following his retirement, he became General Secretary of the Hellenic Red Cross,[1] and served as Minister of National Defence under Sofoklis Venizelos between 30 July and 27 October 1951,[2] and as Minister for Northern Greece from 5 March to 17 May 1958 in the interim government of Konstantinos Georgakopoulos.