Panama sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016.

Almengor ranked eleventh out of twelve athletes in the men's shot put F54–55 competition and Romero placed in the same position in the women's javelin F55–F56 event.

[9] Francisco Cedeño Almengor is paralyzed from the waist down due to spinal cord injuries he sustained by a June 2003 automobile accident caused by an intoxicated driver in La Chorrera and he has used a wheelchair since.

[13] On 16 September, he took part in the men's shot put F54–55 competition, finishing eleventh out of twelve athletes who started the event, with a throw of 9.16 metres.

[16] She was left paralyzed from the waist down after an automobile driven by an allegedly intoxicated driver collided with her vehicle and sent it down a ravine in Campana on 19 July 2009.

[2][17] Romero stated before the Paralympics that while she was nervous about competing, she promised to perform to the best of her ability,[16] and vowed to improve her personal best mark.