It is served by Sydney Trains' T8 Airport & South Line services.

Panania station opened on 21 December 1931 when the line was extended from Kingsgrove to East Hills.

[3][4] On 9 December 1985, the line from Revesby to East Hills was duplicated with a new track laid to the north of the existing one.

[8] In July 2018, the upgrade was completed which included new lifts, stairs, weather canopies, signage, refurbishments, toilets and CCTV.

Braesmere Road Anderson Avenue/Weston Street Panania station is served by one NightRide route.