"Pandora's Kiss" / "Don't Give Up" is a double A-side single by English singer Louise.

The single was also released to raise money for the Tickled Pink campaign for Breast Cancer Care.

It was re-released in 2019, being available on music download outlets and streaming to coincide with the release of Louise's fourth studio album, Heavy Love (2020).

A music video for "Pandora's Kiss" was directed by Trudy Bellinger and filmed on 24 July 2003 at Asylum Studios, London.

During the second verse, Louise enters another room inside the box where she dances in front of a wall of television screens.