Panetolikos was founded in 1926 and is considered one of the historical clubs in Greece, currently participating in the Greek First Division.

Some of the most well known players that started their career in the club are Stratos Apostolakis, former Greek recordman in international caps (96), and Petros Michos.

[1] Panetolikos was founded on Tuesday March 9, 1926 with the purpose, as stated in its statutes: "The development and intensification of Gymnastic and Racing, The -ETHIC- supervision and the possible after-school education of minors, through childhood and EASTERN or Sunday schools".

Hundreds of poor children learned letters at Night Schools that worked and cared for themselves in society.

[5] In the summer of 2005, the new Greek owner Fotis Kostoulas,[6] coming from Sweden and wanting to take the reins of the city team from which he came, presented his plans for the future of the club and followed a radical refurbishment of the stadium.

[7] Panetolikos won an epic play-offs tie against fellow third-tier side Rodos to win promotion to the Beta Ethniki for the 2009–10 season.

[8] The tie was played in Athens at the Nea Smyrni Stadium, in front of full house, with 8,000 loyal fans traveling from Agrinio to support the team.

After terrific performances inside and outside Agrinio, Panetolikos won the last three critical matches (Ethnikos-Panetolikos 0–1, Panetolikos-Diagoras Rodou 3–0 and Ilioupoli-Panetolikos 2–3) and promoted to Super League.

This was the situation until 2005, when the new owner of the club, Fotis Kostoulas, revealed his plans for the complete reconstruction of the stadium.

2011: Works have begun after the promotion of the team to Super League in order to increase the capacity of the stadium by 1,400 seats approximately.

[24] 2019: Recently the Region of Western Greece has approved plans of further upgrade of the stadium, with the adding of exhibition centers, new seating stands and many other features.

Soccer fields, swimming pools, courts, tennis, basketball and beach volleyball create a unique place.

First division promotion has set in motion more Panetolikos fan clubs in Aetoloakarnania and northern Greece (Thessaloniki).

Another nickname is Agriniotes, because the team is settled in Agrínio National (7) Regional (2) Panetolikos crest depicts Titormus, the ancient hero of Aetolia.

The club's motto (also depicted on the crest) is Τίτορμος Αιτωλός Ούτος Άλλος Ηρακλής, translated as Titormus the Aetolian is another Heracles.

Current sponsorships: Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.