Some of the well-known players that have played with the club over the years have included: Faidon Matthaiou, Takis Koroneos, Makis Dendrinos, Dimitris Fosses, Kostas Missas, Fanis Christodoulou, Giannis Giannoulis, Boban Janković, P. J.

Brown, Panagiotis Giannakis, Henry Turner, Thurl Bailey, Travis Mays, Žarko Paspalj, Byron Dinkins, Mitchell Wiggins, Theo Papaloukas, Jure Zdovc, Laurent Sciarra, Nikos Chatzis, Georgios Sigalas, Angelos Koronios, Dimos Dikoudis, Nikos Oikonomou, Georgios Diamantopoulos, Stratos Perperoglou, Michalis Pelekanos, Ender Arslan, Miloš Vujanić, Alex Stepheson, Errick McCollum, and Tyrese Rice, among others.

After the Greek military suffered defeat in the Greco-Turkish War in 1922, the club was transferred to the Athenian suburb of Nea Smyrni, in Greece.

In 1991, led by Fanis Christodoulou, the team won the Greek Cup title, by defeating PAOK by a score of 73–70.

Ιn the 1993–94 season, after an exciting run in the European 3rd-tier level FIBA Korać Cup, and after scoring a couple of wins against Maccabi Tel Aviv in the quarterfinals, Panionios reached the semifinals, and played against PAOK Bravo.

Two years later, in 1999, Panionios once again reached the semifinals of the FIBA Korać Cup, where they were again eliminated, this time from the super favorites of the tournament, FC Barcelona, which featured Sasha Djordjević.

In the Greek League 2007–08 season, under the ownership of Elias Lianos, the founder of Proton Bank, Panionios, led by Ivan Zoroski, Giannis Kalampokis, and charismatic head coach Nenad Marković, finished in 3rd place in the Greek League.

[3] For the 2015–16 season, Panionios preferred to play in the third-tier of Greece, the semi-pro level Greek B Basket League, due to financial difficulties.

Due to financial difficulties, Panionios was demoted down to the Greek 3rd Division, prior to the 2020–21 season.

[7] In 2019, the club moved into the Sofia Befon Palaio Faliro Indoor Hall for the 2019–20 season.

Rest of Americas: Africa: Oceania: Panionios team leaders in games played and points scored, since the Greek Basket League became fully professional, starting with the 1992–93 season.