Among the many attending the school is the troubled daughter of Tyr, the (seemingly) suicidal son of Hades, the popular daughter of the Egyptian sun God Ra, and the extremely lucky son of Benten, the Japanese goddess of luck, love and the arts.

Several of the more amoral children develop a plan to become full blown gods, leaving only a few of the students to oppose them.

Book two begins with two of the protagonists attending another school as the repercussions of the Pantheon High events are still being worked out.

Additionally, once everyone returns to Pantheon High, the protagonists discover a plot by four evil gods—Chronus, Susano, Set, and Loki—that could result in the destruction of their friends and all other divinities.

At the same time, the masterminds of all the evil deeds thus far complete their plans and brainwash all the other students as well as their divine parents.