Panthersville is an unincorporated community and census-designated place (CDP) in DeKalb County, Georgia, United States.

According to the United States Census Bureau, the CDP has a total area of 3.7 square miles (9.6 km2), of which 0.27% is water.

[15][14] As of the 2020 United States census, there were 11,237 people, 4,036 households, and 2,251 families residing in the CDP.

Panthersville is home to the Gallery at South DeKalb, formerly South DeKalb Mall, a regional shopping center with a Macy's (former Rich's) department store.

[23] The CDP is incorporated within the DeKalb County Public Schools zone:[24]