Pants Off is the third home video release and thirteenth Bravo stand-up comedy special by stand-up comedian Kathy Griffin and her fifteenth overall.

It was televised live from the Segerstrom Center for the Arts in Costa Mesa, California on September 20, 2011 (2011-09-20),[2] on Bravo.

It was released simultaneously with Tired Hooker.

It was originally titled "Kathy Griffin: Pray The Gay Back".