The show revolves around the exploits of the Anarchy sisters, Panty and Stocking, angels who were kicked out of Heaven due to their bad behavior.

[2] Hiromi Wakabayashi, who provided the initial idea for the series, cited American adult animation, such as Drawn Together, as inspiration for the show's crudeness.

The series' animation is done in a distinct style resembling and paying homage to American cartoons, along with the Yoshinori Kanada techniques normally associated with Hiroyuki Imaishi's work.

On terrestrial television, it was syndicated in eight markets, including a few JAITS members like Tokyo MX, and TVQ, a TXN affiliate in Fukuoka Prefecture.

[16] On November 25, 2016, the official Twitter account for Gainax West posted an announcement teaser image featuring silhouettes of Panty and Stocking with the words "Comming [sic] Soon".

An announcement for "something new with Panty & Stocking with Garterbelt" was to be made on December 16, 2016, which Gainax West stated would not be a pachinko, pachislot, social network game, or Blu-ray.

Some strips were included in the Panty & Stocking with Garterbelt: Datencity Paparazzi art book, released on June 4, 2011, but the series has not been published in tankōbon format.

[31] IGN also listed Panty & Stocking with Garterbelt among the best anime series of the 2010s, describing it as "an irreverent, entertaining joy-ride with dozens of tributes to western cartoons and a bangin' soundtrack".

[33] Anime News Network's individual episode reviews were equally critical, accusing the series more than once of having a style-over-substance approach and generally flawed, tasteless and needlessly disturbing comedy in spite of its impressive production values.

[36] However, David Brothers of Comics Alliance claims that the series feels like the result of an "unholy union" between The Ren & Stimpy Show and Dirty Pair.

"[37] Mike LeChevallier of Japanator says that "where plot structure is hit or miss, the pure stylization, soundtrack and memorable characters make this a series one worth watching from start to finish.