Paolo continued to build his career with the release of another album, self-titled, which contained the single, "Si enamorarse".

Paolo Meneguzzi's Italian debut occurred with his participation in the Young Artists section at the Sanremo Music Festival in 2001.

In 2004, he released the single "Guardami negli occhi (prego)", which reached fourth place with 127,346 votes at Sanremo, and the new edition of Lei è was released, containing an additional song, Baciami, and the remixes of "Lei è" and "Verofalso", in addition to the song from Sanremo.

After two years of silence, he announced his participation in the Festival di Sanremo and of the release (on 9 March) of the album Musica.

On 2 November, the fan club gathering with the artist took place in the studios of Radio Italia in Cologno Monzese.

On 26 November 2007, it was announced that Meneguzzi would be representing his home country Switzerland in the Eurovision Song Contest 2008 in Belgrade, Serbia, competing with the pop ballad "Era stupendo".