Papyrus 21 (in the Gregory-Aland numbering), designated by siglum 𝔓21, is an early copy of the New Testament in Greek.

The manuscript paleographically had been assigned to the early 4th century.

[1] The manuscript is written in large upright uncial letters.

[2] The Greek text of this codex probably is a mixture of text-types.

[1] In Matthew 12:25 it has textual variant ιδων δε (instead of ειδως δε) in agreement with Codex Bezae, corrector b of the Codex Sinaiticus, 892*, the Latin text of Codex Bezae (itd), k, c, s, copbo.