Based on the by then antiquated principle of maintaining harmony between the microcosm and macrocosm, Paracelsianism fell rapidly into decline in the later 17th century with the rise of the scientific movement,[1] but left its mark on medical practices.
Spagyric, or spagyria, is a method developed by Paracelsus and his followers which was thought to improve the efficacy of existing medicines by separating them into their primordial elements (the tria prima: sulphur, mercury, and salt) and then again recombining them.
Paracelsian physicians held that through this method the medically beneficial ingredients of a compound (the purified tria prima) were separated from the harmful and toxic ones, turning even some poisons into medicines.
These processes were in use in medieval alchemy generally for the separation and purification of metals from ores (see Calcination), and salts from brines and other aqueous solutions.
[citation needed] Originally coined by Paracelsus, the word comes from the Ancient Greek σπάω spao ('to separate, to draw out') and ἀγείρω ageiro ('to combine', 'to recombine', 'to gather').