It is organized by the Paraguayan Football Association in the Asunción metropolitan area, and by the Unión del Fútbol del Interior in the rest of the country.
The winners, and sometimes runners-up of each tournaments are promoted to División Intermedia, the second-tier in the Paraguayan football league system.
Only teams from the Gran Asunción area a take part in this third division league.
Since 2014, in even years the champion does not earn direct promotion, but gets the chance to play a repechage against the runner-up of the Primera División B, in odd years the champion is directly promoted and the runner-up is the one who wins the right to play the repechage.
The Campeonato Nacional de Interligas is the biggest football event involving teams with combined players from different clubs of every regional leagues in Paraguay from all departments.