It is located about 1.8 kilometres (1.1 mi) west-south-west from city centre of Pardubice, and an important railway network hub.

Factories in the city built industrial sidings to the main station: 37 lines had been constructed in 1908 and new ones were added after the war.

Their design was a single floor large passenger hall with complete infrastructure connected to a seven-story administrative building.

The station has connections to Prague, Brno, Vienna, Bratislava, Budapest and other cities and is served by InterCity, EuroCity, Pendolino and local trains.

In station operates also LEO Express with comfortable trains to Prague, Olomouc, Ostrava and Košice and RegioJet.

Reconstruction of stations in Pardubice and in neighbouring Hradec Králové is planned as of 2005 with intent to make them more attractive to the public.

Small railway stations in Svítkov and Rosice nad Labem, districts of Pardubice, handle local traffic.