Parima Tapirapecó National Park (Parque Nacional Parima Tapirapecó) is a Venezuelan national park in the southern state of Amazonas.

The Parima Tapirapecó National Park is in the Atabapo and Río Negro municipalities.

Established in August 1991, it has an area of 38,290 km2 (15,000 mile²), and is the largest national park in Venezuela.

The area protects the headwaters of the Orinoco, likewise the natural space and culture of the Yanomami ethnic group.

There are also large areas of mostly secondary savannas in the southern Parima uplands.