[2] The Paris–Mulhouse railway leaves the Gare de l'Est in Paris in eastern direction.

It leaves the Aube and enters the upper Marne valley at Chaumont.

It passes Langres and the railway junction Culmont-Chalindrey, where it crosses the line Nancy–Dijon.

It turns east, passing Lure, Belfort, Dannemarie and Altkirch.

The sections between Nogent-sur-Marne and Flamboin-Gouaix, between Troyes and Langres, and between Dannemarie and Mulhouse were opened in 1857.