The District employs more than 600 staff members who provide education for approximately 4,500 students.

The district headquarters is the Jefferson Early Childhood Center at 8200 Greendale Ave in Niles.

[2] District 64 is governed by a board of education composed of seven members, President Dr. Denise Pearl, Vice President Monica Milligan, Secretary Matt Doubleday, Phyllis Lubinski, Gareth Kennedy, Rachel Georgakis, and Demetri Touzios.

The district's current superintendent is Dr. Benjamin "Ben" D. Collins who assumed powers on July 1, 2023, after being Principal at Maine South High School, part of Maine Township High School District 207, in Park Ridge, Il.

"[9] By 1902, School District 2, Township 41 North, Range 12 East, "Park Ridge", had an "old building" constructed for $6,000 in 1868 on 0.6 acres (0.24 ha) and a "new building" constructed for $20,000 in 1893 on 6.0 acres (2.4 ha)[10]: 53  near the southwest corner of township section 26.