The Parkersburg–Belpre Bridge is a four-lane cantilever bridge that connects Parkersburg, West Virginia, to Belpre, Ohio, across the Ohio River.

The bridge had been signed U.S. Route 50 (US 50) until June 13, 2008, when that highway was re-routed to the Blennerhassett Island Bridge a few miles to the west, as part of the completion of the Corridor D project around Parkersburg.

The American Discovery Trail uses the bridge to cross the Ohio River.

The bridge was designed by Hermann Lamb and built by the John A. Roebling's Sons Company of New Jersey.

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