In 1901, the Archdiocese of Santiago gave permission for the construction of a church on the site of the old chapel.

On Christmas Eve of 1902, the parishioners requested the construction of a church in honor of St. Vicent Ferrer and a chapel dedicated to Our Lady of Andacollo.

reported in 1987 that, in spite of extensive archival research, he could not uncover the reason for the change, but, from 1903 forward, the community would be referred to as the "Sanctuary of Our Lady of Andacollo."

By 1912, the Sanctuary had grown in importance to the neighborhood that it was necessary to give it the designation of parish with Rev.

In 1943, Nicomedes Guzmán wrote his novel about the poverty of the neighborhood, "La sangre y la esperanza" [The Blood and the Hope], that frequently marks the presence of the parish in the life of the poor by the sound of the church's bells in key moments of the novel.

In 1915, the parish formed a conference of the Society of Saint Vincent de Paul.

The parish serves long-time residents of the neighborhood as well as a growing immigrant population from Peru, Bolivia, Ecuador, and Colombia.

FundaMor, the Congregation of Holy Cross' foundation that supervises homes for children in Chile, launched a "prevention" project in the parish.

Almost a year to the day later, on December 6, 1986, the church was rededicated in a celebration of the Eucharist, presided over by Cardinal Juan Francisco Fresno, then Archbishop of Santiago.