It stars an ensemble cast comprising Frank Langella, Gena Rowlands, Rosario Dawson, Penn Badgley, Teresa Palmer, and Josh Hartnett as three loosely connected couples who must deal with a looming biological attack.

Apprehensive after watching news reports of increasing conflict in the Middle East, Anna comes to believe that they should spend more time together, but Erik seems preoccupied with music composition and maintaining friendly relations with his ex-girlfriends.

Mia, an accomplished lawyer, has just successfully represented Andy, a scientist of some renown, from accusations of selling trade secrets to a research facility in the 1970s.

Anna, worried about visions that she has had recently of a looming apocalypse that involve a young girl, confides in Rick, Len's best friend, that she fears she may be suffering from schizophrenia.

Although Andy admits that he knew that the research was likely unethical, his wife, Esther, brushes off his guilt and says that the money kept their daughter alive long enough to give birth to Eric.

[4][5] On December 12, 2012, AKA/Bow Street Films announced that Teresa Palmer, Penn Badgley, Hill Harper and Alexis Bledel had joined the cast.

[9] Thomas Spurlin of DVD Talk rated it 2/5 stars and wrote that the film is too pessimistic and heavy-handed to properly address its philosophical themes.

[10] Bill Gibron of DVD Verdict wrote, "This lame, loosely knitted nonsense tries to bring the end of the world down to a human level and fails over and over again.