It originally the served the Louisville and Nashville Railroad but was most recently a stop for Amtrak.

[4] Former Louisville & Nashville services which utilized their station included the Crescent (New Orleans–New York), Pan-American (New Orleans–Cincinnati) and Humming Bird (New Orleans–Chicago and Cincinnati).

Amtrak service began with the Gulf Coast Limited, which operated between 1984 and 1985 and called at the station.

[8] Damage to the rail line resulting from Hurricane Katrina in 2005 caused Amtrak to suspend service east of New Orleans,[1] including at Pascagoula.

This article about a property in Mississippi on the National Register of Historic Places is a stub.