Her credits include Sonatine (1984), Eldorado (1995), When Night Is Falling (1995), August 32nd on Earth (Un 32 août sur terre) (1998), Bittersweet Memories (Ma vie en cinémascope) (2004), Afterwards (2008), The Demons (Les Démons) (2015), Death of a Ladies' Man (2020), Bootlegger (2021), and Frontiers (Frontières) (2023).

Born in Montreal, Quebec, Canada,[1] Pascale Bussières first played a suicidal teenager in Micheline Lanctôt’s 1984 film Sonatine.

[1] She played the role of a prim-and-proper mythology teacher who discovers her lesbian desires in Patricia Rozema's When Night Is Falling.

[1] She appeared as an alienated fashion model who wants to conceive a child in Denis Villeneuve's debut feature, August 32nd on Earth (Un 32 août sur terre) (1998),[1] and won Prix Iris for Best Actress at the 7th Jutra Awards, and for Best Performance by an Actress in a Leading Role at the 25th Genie Awards, both in 2004, for her impersonation of Quebec singing star Alys Robi in Bittersweet Memories (Ma vie en cinémascope).

[2][3] \other credits include The Demons (Les Démons) (2015),[1] Death of a Ladies' Man (2020),[1] Bootlegger (2021),[1] Frontiers (Frontières) (2023).