[4][5] The Eudora area was home to various Native American tribes for thousands of years.

A Kansa village was located at the site of modern day Eudora in the 1790s.

In the 1820s the Kansa were forcibly removed from the region by the U.S. government to make room for the Shawnee tribe.

In 1854 the Kansas–Nebraska Act was passed, creating the Kansas Territory and opening the region to settlement by Americans.

As a result of the Kansas–Nebraska Act, Americans settlers started to encroach upon Indian lands.

In 1856, three members of a German Immigrant Settlement Company (called Deutsche-Neusiedlungsverein) from Chicago, sent out a location committee to choose a town site in the new Kansas Territory.

Favoring the Eudora area, they drew up contracts with Shawnee Chief Paschal Fish, the original owner of the town site.

[6] The new town was named Eudora in honor of Chief Fish's daughter.

[10][11] Eudora was the site of conflict during the Bleeding Kansas Era and the American Civil War.

Eudora strongly supported the Union during the Civil War, many of its men enlisted to defeat the Confederacy.

William Quantrill passed through the Eudora area in 1863 on his way to Lawrence, Kansas to commit his infamous and deadly raid on the unsuspecting town.

Several Eudora residents attempted to warn Lawrence of Quantrill's proximity, but two men were thrown from their horses, one of them dying as a result of his injuries.

After the raid, Eudorans were quick to aid the citizens of Lawrence as they started their recovery.

[12] Eudora is part of the Lawrence, Kansas Metropolitan Statistical Area.

The 2020 United States census counted 6,408 people, 2,296 households, and 1,643 families in Eudora.