Burrell took over as San Francisco's left fielder and hit 18 home runs in 96 games for the Giants, helping to lead them into the playoffs.

The following year, he signed a one-year deal to return for the Giants’ 2011 season; however, Burrell ultimately lost his left field job, as he batted .230, with a career-low 7 home runs, in 92 games, while battling what would be a career-ending foot injury.

On May 19, 2012, at Citizens Bank Park, prior to the Phillies-Boston Red Sox game, Burrell threw out the ceremonial first pitch and subsequently retired.

[2] In March 2012, Burrell was named as a special assignment scout for the Giants and an assistant to General Manager (GM) Brian Sabean.

[4] After his freshman year, he transferred to Bellarmine College Preparatory in San Jose, where he played baseball and football.

[14][15] He spent most of the season with the Double-A Reading Phillies of the Eastern League, batting .333 with 28 home runs and 90 RBI in 117 games.

[17][18][19] Making his major league debut that day, Burrell had two hits (his first coming against Octavio Dotel) and two RBI in a 9–7 victory over the Houston Astros.

[28] Burrell finished the season with 18 home runs, 79 RBI, and a .260 batting average in 111 games, and received the fourth most votes for the NL Rookie of the Year Award.

[39] Burrell hit a leadoff walk-off home run on April 7, 2002, in the 11th inning, giving a 3–2 victory over the Florida Marlins.

[40] Three days later, Burrell hit a two-run, walk-off home run in the 11th inning to give the Phillies a 7–5 victory over the Braves.

[6] Burrell finished the season with career highs in almost every offensive category, including runs (96), batting average (.286), and games (157).

[6][52] Burrell endured a season-long slump, and he was occasionally benched for a few games (often in favor of Ricky Ledée) by Phillies' manager Larry Bowa.

He also made a leaping catch to take a home run away from Rolen, and he threw out Pujols trying to score from third base on a single by Édgar Rentería.

[59] On August 3, Burrell strained his left wrist during batting practice, and he was placed on the disabled list (DL) for the first time in his career the next day.

[76] Burrell finished the season batting .281 with 32 home runs in 154 games, and he set career highs in walks (99) and RBI (117).

[6][77] On defense, however, he tied for the lead among all major league left fielders in errors, with seven, and the lowest fielding percentage among them, at .972.

[6] However, he batted .249 for the rest of the season, and in June Philles' manager Charlie Manuel began benching him occasionally (often in favor of David Dellucci).

[84] On June 9, he had three RBI, including a two-run home run against Gary Majewski, but the Phillies lost, 9–8, to the Washington Nationals.

[99] Werth was injured at the end of June, however, and Burrell reclaimed his starting job by batting .435 in July, with six home runs and 22 RBI.

[104] Two days later, in the third game of the series, he hit a solo home run and had a sacrifice fly (the game-winning RBI) against Óliver Pérez in a 3–2 victory.

[107] Burrell finished the 2007 regular season batting .256 with 30 home runs, 97 RBI, and 114 walks (a career high) in 155 games.

[115] His walk-off two-run home run with two outs in the tenth inning gave the Phillies a 6–5 victory over San Francisco on May 2.

[124] Four days later, in the first game of the NL Championship Series, he hit a game-winning solo home run in a 3–2 victory over the Dodgers.

Burrell was then replaced by pinch-runner Eric Bruntlett, who scored the game's winning run in the 4–3 victory as the Phillies won their first World Series since 1980.

[128] On December 16, the Phillies signed left fielder Raúl Ibañez to a three-year contract, ending Burrell's tenure in Philadelphia.

[131] On April 9, Burrell flew to Philadelphia to join the Phillies as they received their World Series rings in a pregame ceremony.

[143] After batting .313 with one home run and six RBI in five games, he was called up to the Giants on June 4 to replace John Bowker, who was optioned to Fresno.

[151] On August 17, Burrell returned to Philadelphia for his first regular season game there as a member of the opposing team, and he received a standing ovation.

[154] In the World Series, Burrell struck out eleven times in thirteen at-bats, had no hits, and was benched for Game 4.

[170] After his playing career ended, Burrell became a special assignment scout for the San Francisco Giants in Scottsdale, Arizona.