Signed by the Red Sox without having previously played any minor league baseball, Creeden made his debut on April 14, 1931.

"[9] In the winter of 1930, the Boston Red Sox signed Creeden and announced the move on December 20,[3] even though he had no prior experience in minor league baseball.

[10] In spring training of 1931, Creeden's promising performance led the Associated Press to suggest that he could replace Bobby Reeves as the team's starting second baseman.

[3][11] After pinch-hitting for two more games against the Yankees, Creeden was finally given a chance to make his fielding debut on April 20 against the Washington Senators.

Although he drew a walk, he remained hitless with two more at bats, committed a throwing error and was eventually replaced by Reeves, prompting the Boston Herald to criticize Creeden's lackluster performance.

[3] The following day, he again started the game and executed what The Washington Post described as a "snappy double play,"[3] but went 0 for 3 at the plate and made an error which loaded the bases.

After the end of the war, he served in the Department of Education branch of the Commonwealth of Massachusetts Division of Youth Service, working as the superintendent of John Augustus Hall in Oakdale, West Boylston until he retired in 1972.