[1] He is a member of Wilco, The Autumn Defense,[2] and Mellotron Variations[3] and has worked with Jonathan Wilson, Andrew Bird, Jamie Lidell, and others.

[6] Sansone attended The University of Southern Mississippi,[7] where he met Will Martin and Eddie Bo McRaney and formed the trio, Beagle Voyage.

In 2004, Sansone joined Wilco before a tour in support of their album A Ghost Is Born, following the departure of multi-instrumentalist Leroy Bach.

He has contributed to albums by Joseph Arthur, Andrew Bird, Josh Rouse, Mavis Staples, Swan Dive, Jenifer Jackson, Ryan Adams, The Clientele, The Milk Carton Kids, Karen Elson, Jonathan Wilson and others.

In April 2012, Sansone and Josh Shapera co-produced an EP, Weird Weather, for the Chicago-based band Future Monarchs.

Pat Sansone co-produced the 2020 released album "Dixie Blur" by Jonathan Wilson and contributed on bass, acoustic guitar, Mellotron, synth, vibes and background vocals.

Sansone produced and played multiple instruments on Emma Swift's album of Bob Dylan covers, Blonde on the Tracks, recorded between 2017 and 2020 in Nashville, Tennessee and also featuring Robyn Hitchcock.

[12] In 2024 Centripetal Force released Infinity Mirrors, an album of Sansone's synthesizer compositions, with "interesting variety and plenty to stimulate the listener"[13] (Poetic Justice Magazine).