Pathfinder National Wildlife Refuge is located in the U.S. state of Wyoming and includes 16,807 acres (68 km2).

Fish and Wildlife Service and the U.S. Bureau of Reclamation, both agencies within the U.S. Department of the Interior.

The refuge is divided into four sections adjacent to Pathfinder Reservoir and includes three campgrounds and three boat ramps.

It is located in southern Natrona and northern Carbon counties.

Pathfinder NWR is managed from the Arapaho National Wildlife Refuge which is located in Colorado.