The Patoka River National Wildlife Refuge and Management Area, established in 1994, is a collection of wildlife refuges and habitats situated along the Patoka River in Gibson and Pike counties in southwestern Indiana.

Many species of birds nest or spend the winter in these areas, including the bald eagle and endangered least tern.

In 2012, tier 1 of the Interstate 69 Project was built through this area immediately west of Oakland City in the strip long been set aside when the original Interstate was built, using a 1.5-mile-long (2.4 km) bridge to lessen the environmental impact.

This has prompted some disturbances by the group Earth First!, including "evicting" the project offices in Oakland City.

[2] This article incorporates public domain material from websites or documents of the United States Fish and Wildlife Service.