The Patras–Kyparissia railway (Greek: Σιδηροδρομική Γραμμή Πάτρας - Κυπαρισσίας) is a railway line of the OSE in Achaea, Elis, and Messenia, southwestern Greece.

This 163 km long single track metre-gauge line connects Patras, Pyrgos and Kyparissia.

[1] The Patras–Kyparissia railway is connected to the following other railway lines: There was a ferry connection from Patras to Kryoneri, the southern terminus of the (now abandoned) railway line to Missolonghi and Agrinio.

The first section from Patras to Kato Achaia was opened in 1888, and to Pyrgos in 1890.

[citation needed] Since January 2011, passenger traffic on most of the line has been suspended.