She then moved to New York City and studied acting in HB Studio for three years at the same time that she took creative writing courses with Robert Auleta in School of Visual Arts.

Other series she has performed in include: La Ley del corazon, Nadie me Quita lo Bailao the film Pacifico directed by Argentinian director GG.

In 2018 she landed the leading role in the series Debora, la mujer que desnudo a Colombia about the painter form Medellin who was banned by the church, silenced by the government and attacked by society for being a woman painting nudes.

On 2005 she wrote her first book Manual para Salir de la Tusa (Guide to get over heart breaks) a funny and satirical piece, published by Editorial Norma, a best seller for over a year in Colombia.

In 2022, it was announced that Castañeda had written and will produce a feature film Estimados Señores, Dear Gentleman, on the life of the late Colombian suffragist with Esmeralda Arboleda Cadavid, starring Julieth Restrepo.

El laberinto de Alicia Nominee 2019 India Catalina Award for Outstanding Performance by a Female Actor in a Leading Role Debora Won 2017 TV y Novelas Award for Outstanding Performance by a Female Actor in a Supporting Role El laberinto de Alicia Won