In 2014, the British Royal Philharmonic Society gave Kopatchinskaja one of its annual Music Awards in the instrumentalist category, calling her an "irresistible force of nature: passionate, challenging and totally original in her approach".

She has ongoing collaborations with conductors including Teodor Currentzis, Péter Eötvös, Iván Fischer, Edward Gardner, Heinz Holliger, Vladimir Jurowski, Andrés Orozco-Estrada, Kirill Petrenko, Sir Simon Rattle and François-Xavier Roth.

[10] Regular chamber music partners include cellist Sol Gabetta, clarinettist Reto Bieri and the pianists Joonas Ahonen, Markus Hinterhäuser, Polina Leschenko and Anthony Romaniuk.

They played Raga Piloo, which Ravi Shankar composed, performed, and recorded as a duet with Yehudi Menuhin on the 1968 album West Meets East, Volume 2.

Kopatchinskaja has collaborated with Il Giardino Armonico, the Akademie für Alte Musik Berlin, MusicAeterna Perm, the Orchestre des Champs-Élysées, the Orchestra of the Age of Enlightenment under the direction of Giovanni Antonini, René Jacobs and Philippe Herreweghe.

She has performed and recorded works by Luca Francesconi, Francisco Coll García, Mark-Anthony Turnage, Sanchez-Chiong, Stefano Gervasoni, Simone Movio, Michael Hersch, Esa Pekka Salonen, Péter Eötvös, Heinz Holliger, and Michel van der Aa.

Her "Time and Eternity" program with Camerata Bern, recorded for Alpha Classics, featured music by John Zorn, Ikonnikow, Tadeusz Sygietynski, Machaut, and Bach, along with Karl Amadeus Hartmann's Concerto Funebre.

In 2010, she briefly played the 1741 "ex-Carrodus" violin by Guarneri del Gesù, on loan from the Austrian National Bank but had to give it back because of unresolvable problems with Swiss customs authorities.

Francis Poulenc Leo Delibes Béla Bartók Maurice Ravel Michael Hersch End Stages, Violin Concerto fcr 208 Time and Eternity alpha545