Located at 617 South Jefferson Street at the southern end of Downtown, the Patrick Henry was designed by William Lee Stoddart and opened in 1925.

[3][4] In 1923, local business leader William Wise Boxley chartered The Hotel Corporation to serve as the developer of the Patrick Henry.

[3] Taking its name from the American Founding Father Patrick Henry, the 300-room hotel celebrated its grand opening the following year on November 10, 1925, with over 2,000 people in attendance.

[3] It was at this time the Monterey Corporation of Parkersburg, West Virginia, renovated the original 300 rooms into 121 hotel and apartment units.

[6][9] After being foreclosed on in 2009 for failing to pay back taxes, the property was purchased by Potomac Realty Capital of Boston for $2 million and subsequently resold to Roanoke developer Ed Walker the following October.