Patrick Hepburn, 1st Earl of Bothwell (died 18 October 1508) was Lord High Admiral of Scotland.
He rose to political prominence after supporting James IV against his father, and was proxy at the King's marriage.
He was one of the leaders of the Confederate Lords who rebelled against King James III of Scotland, and he led the vanguard against the Royal array at the battle of Sauchieburn, 11 July 1488.
His son and heir Adam Hepburn, 2nd Earl of Bothwell was made Master of the Royal Stables.
He was one of the diplomats sent to conclude the treaty for the marriage of James IV with Princess Margaret Tudor of England in October 1501, and he stood proxy for the King at the ceremony of betrothal on 25 January 1502 at Richmond Palace.