In 2013, Wisdom played with the Peoria Chiefs and Palm Beach Cardinals, batting a combined .235/.313/.401 with 15 home runs, 73 RBIs, and 137 strikeouts in 129 total games between both teams.

[4][3] Wisdom returned to Springfield in 2015 where he batted .237/.294/.406 with 14 home runs, 61 RBIs, and 107 strikeouts (7th in the Texas League) in 114 games.

[14] On April 7, 2019, Wisdom was recalled to the major league roster when Ronald Guzmán was placed on the injured list.

[18] On November 27, 2019, Wisdom signed a one-year major league contract with the Seattle Mariners.

On August 23, 2020, Wisdom signed a minor league contract with the Chicago Cubs organization.

Wisdom signed a minor league contract with a non–roster invitation to spring training with the Cubs for the 2021 season.

[24] On May 31, Wisdom hit a pair of solo home runs in a Wrigley Field game against the San Diego Padres.

On June 7, Wisdom was named the NL Player of the Week, after hitting .435 (10-for-23) with a 1.719 OPS and 6 home runs.

He also became one of three players to hit as many as seven homers within their first eight starts with a team, joining Colorado Rockies shortstop Trevor Story (2016) and Cincinnati Reds outfielder Aristides Aquino (2019).

[27] Wisdom finished the 2021 season batting .231/.305/.518 with 28 home runs, 61 RBI, and 163 strikeouts (9th in the NL) in 106 games.

[35] On December 26, 2024, Wisdom signed a one-year, $1 million deal with the Kia Tigers of the KBO League.