The Patterson Homestead is a historic house museum located at 1815 Brown Street in Dayton, Ohio, United States.

It was built in 1816 by American Revolutionary War veteran Colonel Robert Patterson.

The house was built using Federal architecture in several sections over forty years.

The home is listed on the National Register of Historic Places in 1976 and is currently operated by Dayton History.

This article about a property in Montgomery County, Ohio on the National Register of Historic Places is a stub.