In 1966, the board of trustees received models for construction of the tower and the White Hall Classroom building.

[7][8] Based on a photo printed in the Lexington Herald-Leader, December 1969 was the first time the university's Board Of Trustees met in the building.

[11] On February 12, 2016, Australian philosopher David Chalmers visited the campus to give a talk entitled "Perception and Illusion in Virtual Reality" on the 18th floor of the tower.

[13] In an article published on December 11, 2018, by the Herald-Leader, which includes $500 million facilities plan to renovate older buildings and construct new ones to accommodate planned enrollment growth over the next five years, the tower's 18th floor was mentioned under the heading "recommended capital project", and if repaired or replaced, would cost $4 million.

[14] Patterson Office Tower was home to the Intermezzo Cafe from 1993[15] until 2022 when the University of Kentucky announced the location would be closed without a replacement.

[3] The tower features a basement that connects the Big Blue Pantry and White Hall Classroom Building.

[21] The water damaged the second, third, and fourth floors, saturating ceiling tiles and carpets, and some computers and documents.