Paul-Antoine Giguère, CC (January 13, 1910 – December 25, 1987)[1] was a Canadian academic and chemist.

Born in Quebec City, he received a Bachelor of Science degree from Université Laval in 1934, and a doctorate from McGill University in 1937 under the direction of Otto Maass.

[1] His research was in infrared and Raman spectroscopy and the determination of molecular and crystal structure.

[6] In 1970-75, his group observed the first infrared and Raman vibrational spectra of hydrogen trioxide (H2O3) in dilute aqueous solution.

[7] In 1976 with Sylvia Turrell, he showed that the weak acidity of hydrogen fluoride is due to the formation of a tightly bound ion pair [H3O+·F−].