In 1955, Blaisdell was hired to create the creature effects for Roger Corman's low-budget film The Beast with a Million Eyes, after which he spent several years designing the monsters for a number of B movies, earning a reputation for working quickly and cheaply.

Forrest J. Ackerman had the monster prop from Beast With a Million Eyes carelessly stored in direct sunlight in his home until it completely dried up and fell apart.

The three-eyed mutant costume from Day the World Ended was pretty much ripped to pieces by fans when it was displayed at several promotional tours.

In the early 1960s, Blaisdell submitted some monster designs for projected films such as Goliath and the Dragon (1960) and Jack the Giant Killer (1962), but they weren't used (he was still paid for his time however).

Producer James Nicholson tried to involve Blaisdell in two planned AIP TV series (Beyond the Barriers of Space and Out of This World), but the shows never got made.

Blaisdell suffered from severe dental problems in later life, and finally died of cancer at the age of 55 in Topanga, California in 1983, around the time that the home video market of the 1980s was beginning to resurrect fan interest in his 1950s films.