[2] Cargnello was originally associated with the punk rock band The Vendettas,[3] which recorded two EPs in the late 1990s before releasing the full-length album It's Happening to You!

"[22] The album, titled Something Dimferent featured vocals by both Cargnello and his son Declan, and was released online only, including a full-length animated video available on YouTube.

In December 2017, a new album was released featuring the music of Cargnello and the lyrics of street poet Siou Deslongchamps, entitled Intense Cité.

[26] In 2020 Cargnello produced and co-composed Jonathan Emile's album Spaces-in-Between for Tuff Gong[27] including the single "Babylon Is Falling" featuring Maxi Priest.

Music journalist T'Cha Dunlevy of the Montreal Gazette wrote "Cargnello hasn’t lost his edge — he has simply refined it.

"[29] Paul Cargnello teamed up with his brother Christopher in 2012 and started a side project called Skinny Bros, together they released several EPs and four full-length albums: Fat Tunes (2012),[30] Countréal (2014),[31] Party Gras (2016),[32] The Beginning & The End (2020).

In 2013 he won the City of Montreal's Outstanding Citizen Award for his work as co-founder and chief organizer of NDG Arts Week in the borough of Notre-Dame-de-Grâce.

[38] Cargnello opened Upper China recording studio in late 2016 and added the title of producer to his list of musical credits.