Fusco is known in particular for his photographs of Robert F. Kennedy's funeral train, the 1966 Delano Grape strike and the human toll of the Chernobyl nuclear disaster.
[6][7] His photography often documented social issues and injustices, such as poverty, ghetto life, the early days of the HIV crisis, and cultural experimentation across America.
[8] His 1966 photos of California's Delano grape strike documented migrant farmworkers' struggles to form a union, supported by Cesar Chavez.
[11][12][13] In the early 2000s, Fusco pursued a personal project he called "Bitter Fruit," documenting the funerals of US service members killed in the Iraq War.
[16] Two hundred of his photographs of the United Farm Workers Organizing Committee and Cesar Chavez, taken during a farm worker's strike in Delano, California, are held by the Library of Congress,[17] as are 1,800 Kodachrome slides taken in June 1968 from the funeral train carrying Robert Kennedy's body from New York City to Washington, D.C., for burial in Arlington National Cemetery.