Lowe finished his career with the Kansas City Chiefs, receiving a championship ring after they won Super Bowl IV.

[1] Lowe attended Oregon State University and played under Beavers coach Tommy Prothro.

He played for the San Francisco 49ers during the 1959 pre-season before being released in the final cut after hurting his ankle before the regular season began.

Chargers general manager Frank Leahy asked Lowe to come out to training camp based on his performance at Oregon State a few years back.

[14] He returned his first touch of the football in the AFL for a 105-yard touchdown in the Chargers' first-ever exhibition game.

2 in the league in rushing, 20 yards behind Abner Haynes of the Dallas Texans,[16] and earned first-team All-AFL honors as a halfback.

[1] He returned and ran for 1,010 yards in 1963, when the Associated Press named him the AFL Comeback Player of the Year.

[17] In the AFL championship game, Lowe rushed for 94 yards on 12 carries, including a 58-yard touchdown, in a 51–10 win over Boston.

[15] In 1965, Lowe was named the AFL Player of the Year by The Sporting News after a then-league-record 1,121 yards rushing and six touchdowns (14-game schedule).

[22] Lowe joined the Kansas City Chiefs as a free agent after all six of their running backs were injured.

[3] Lowe was a four-time All-AFL selection, including twice on the first team, as well as a two-time AFL All-Star.

[30] He averaged 4.9 yards per carry during his career, which is the highest in Chargers franchise history and tops in the AFL.

[14] In 1970, the Pro Football Hall of Fame named Lowe as a running back on the All-Time All-AFL Team.

In 2018, Lowe signed papers that awarded him $25,000 (before lawyer fees) from the NFL concussion settlement.