Scheer also co-created and starred in MTV's Human Giant and Adult Swim's series NTSF:SD:SUV::, and has had recurring roles on ABC's Fresh Off the Boat[3] and HBO's Veep.

[10][17] They performed long-form improvisation to sold-out crowds every Saturday night for over five years and starred in a political sketch comedy show called George Bush is a Motherfucker.

[18] In 2002, Scheer created and starred in Automatic Vaudeville at the Ars Nova theater, which The Hollywood Reporter called "one of the top five shows in the country".

The show, which originally featured a panel of comedians including Scheer, shifted to a single host format under Paul F. Tompkins and provided comedic commentary on popular culture.

[34] In 2009, Scheer created a 15-minute spoof commercial for an action series called NTSF:SD:SUV:: (National Terrorism Strike Force: San Diego: Sport Utility Vehicle), that aired on Adult Swim.

The cast included Kate Mulgrew, Rebecca Romijn, Martin Starr, June Diane Raphael (Scheer's wife), Rob Riggle, Brandon Johnson, and the voice of Peter Serafinowicz as S.A.M.

[37] In 2015, Paul Scheer joined the cast of Fresh Off the Boat, an ABC comedy loosely based on a memoir by chef Eddie Huang.

In 2017, Scheer joined the sixth season of Veep as the character Stevie, the producer of CBS Morning News Show.

[41] In 2020, Scheer returned to the cast of Veep along with other special guests, including Don Cheadle, Mark Hamill, Beanie Feldstein, Stephen Colbert, and Bryan Cranston in a live table read playing multiple roles to support turnout for the Georgia runoff elections.

[56][57] In addition to acting, Scheer has produced The Hotwives for Hulu, Party Over Here for Fox, Drive Share for Go90, Filthy Preppy Teen$ for FullScreen, The Amazing Gayle Pyle for Seeso, and Unsend for Comedy Central.

[58][59][60][61][62][63] In 2016, in addition to executive producing Party Over Here, Scheer created and directed segments for the late-night sketch comedy series with The Lonely Island.

[70] In 2017 Scheer produced and starred in Playdates, the first independent pilot to debut at Sundance Group, alongside Carla Gallo.

[73] In 2021, Scheer's YouTube web series, Marvel Presents The World's Greatest Book Club, won an honorary Webby for best reality program.

"[75] Guests have included Kevin Smith, Damon Lindelof, "Weird" Al Yankovic, Danny Trejo, Vanilla Ice, Adam Scott, Tatiana Maslany, and Nick Kroll.

[82] Unspooled was well received by the press, earning top reviews from Esquire, Vanity Fair, Town & Country, Vulture, and Rolling Stone.

[91] Scheer and Giovanetti continued their collaboration with Marvel Comics, where they penned Deadpool Bi-Annual #1, a Guardians Team Up,[92] which were released September 2014 and 2015.

Scheer and Giovanetti have also written for DC Comics: Harley Quinn: Black + White + Redder, #1 (Get Gaggy); The Harley Quinn short story "It's a Horrible Life" which he co-wrote with Nick Giovanetti, Steve Lieber, Marissa Louise, and Carlos M. Mangual; and Batman: The Audio Adventures Special, a prequel to the podcast series Scheer voiced.

[94][95][96] In May 2024, Scheer released his memoir "Joyful Recollections of Trauma," which quickly became a New York Times Bestseller for Hardcover Nonfiction.

The performers included Stiller, Will Ferrell, Ashton Kutcher, Demi Moore, Aziz Ansari, the cast of It's Always Sunny in Philadelphia, Dane Cook, Wilmer Valderrama, John Cho, Mindy Kaling, and Sasha Grey.

[105] Scheer also helped organize The Big 100, a program that asked Americans to take progressive actions in the 100 days following President Donald Trump's inauguration.

[106] On November 2, 2022, Scheer told Twitter followers that his mail-in ballot had not arrived and thanked nonpartisan voter advocate organization VoteRiders for letting him know what credentials he needed to vote in person.

[107] In 2023, Scheer co-hosted "The Give Back-ular Spectacular," a live telethon-style fundraiser at the Orpheum Theatre in Los Angeles, which raised funds to support TV and film crew members affected by the WGA and SAG-AFTRA strikes.

[108][109] Scheer and June Diane Raphael hosted the 2024 Humanitas Prizes event, supporting writers who explore the human condition and raising funds for programs like the New Voices Fellowship and College Screenwriting Awards.

[115] They first met in January 2004, after the artistic director of Manhattan's Upright Citizens Brigade Theatre brought Scheer in to offer tips to Raphael and her comedy partner, Casey Wilson, on improving their UCB two-woman sketch show and started dating shortly afterward.

[117][118] Scheer has frequently vacationed at Walt Disney World since childhood; in 2020, he said he had outgrown the reliance he had on the park when he was younger, but said that it remained "such a part of my life, for better or worse" and that he enjoyed visiting with his children.