A 6'1" guard, Seymour played collegiately at the University of Toledo, and had a 12-year career in the NBA and its predecessor, the Basketball Association of America (BAA).

Seymour still shares, with former teammate Red Rocha, the NBA record for most minutes in a playoff game with 67.

Seymour was mentioned in the ESPN documentary, Black Magic, which told the story of African-Americans and basketball.

Seymour had no ill feelings towards team owner Ben Kerner, stating, "He didn't fire me.

Seymour was elected to the first class of the Greater Syracuse Sports Hall of Fame in 1987 along with owner Dan Biasone and NBA all-time great Dolph Schayes.