She had her breakout role as the tomboyish girl Willie Jack on Reservation Dogs, a performance which garnered critical attention.
[11] Alexis' next role was as April in the award-winning Canadian film Beans (2020), a semi-autobiographical story written and directed by Tracey Deer (Mohawk) about the Oka Crisis at Kanesatake, Quebec.
[13] Alexis has said that being on the set of Beans was incredibly fun, Deer allowed her to improvise some of her lines, and she met her future Reservation Dogs co-star D'Pharaoh Woon-a-tai.
[14] Alexis originally auditioned for the role of Elora, a female lead in Reservation Dogs,[7] but Kawennáhere Devery Jacobs was chosen to play her.
"[16] Jenelle Riley writes for Variety, "It’s cliché to talk about young actors being older than their years, but Alexis delivers wisecracks with the timing of an old pro - her one-liners are as memorable as her hats.
"[19] Alexis is also featured as the character Immpy in the film Bones of Crows (2022), an inter-generational tale about a family of Indigenous women, who are living with the traumas inflicted by genocidal Indian residential schools.
[20] Alexis had a voice acting role in Inkwo for When the Starving Return, a stop motion animation interpretation of Richard Van Camp's short story "The Wheetago", presented by Spotted Fawn Productions.