Isiro (pronounced [iˈsiro]) is the capital of Haut-Uele Province in the northeastern part of the Democratic Republic of the Congo.

[2] Most people speak, Pa-Zande (Zande language), Lingala, Swahili and which is somehow uncommon.

[3] In the troubled days of Congo's independence and its aftermath, operation Black Dragoon brought fighting between Belgian paratroopers and local Simba militias.

In 1998, Isiro became the home of a newly created Dominican-operated university called Université de l'Uélé.

The dirt roads to and from Isiro allow commercial trade with Uganda and South Sudan, in principle, but may be impassable in the wet season.